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Christina Applegate details physical toll of MS battle

Since her 2021 diagnosis, the “Dead to Me” star has been openly documenting the "unbearable" physical toll of the disease, noting that chronic pain now dictates much of her daily life.

News Arena Network - Los Angeles - UPDATED: February 25, 2026, 01:41 PM - 2 min read

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Applegate is now planning on releasing a memoir, “You With The Sad Eyes”, a book about her battle with the illness, growing up as a child star, and enduring abuse.


In a heart-breaking health update, actor Christina Applegate has shared that her battle with Multiple Sclerosis (MS) has now largely confined her to bed.

 

Since her 2021 diagnosis, the “Dead to Me” star has been openly documenting the "unbearable" physical toll of the disease, noting that chronic pain now dictates much of her daily life.

 

Despite these gruelling limitations, Applegate remains determined to show up for her 15-year-old daughter, Sadie, pushing through the exhaustion to handle school runs and essential activities.

 

“I want to take her; it’s my favourite thing to do. It’s the only time we have together by ourselves,” the 54-year-old actress said in an interview.

 

“I tell myself, ‘Just get her there safely and get home so you can get back into bed.’ And that’s what I do.”

 

Applegate is planning to release a memoir, “You With The Sad Eyes”, a book about her battle with the illness, growing up as a child star, and enduring abuse.

 

Also read: Bella Hadid reflects on Hollywood pressures during Lyme battle

 

The book, set for release on March 3, will detail how childhood was for Applegate, who grew up with a single mom in California. The book will also shed light on domestic abuse and molestation that the actor endured in her early life.

 

Applegate is the daughter of actress Nancy Priddy, who struggled with heroin addiction and had an abusive boyfriend. “I think I had kind of the worst situation from [ages] 3 to 7, but there was stuff like that going on in all our homes,” she said.

 

Applegate later found herself in a romantic relationship marked by violence. “My mom always said, ‘I never met a junkie I didn’t like.’ And that kind of was how I rolled,” she admitted.

 

She had previously shared about her late boyfriend Lee Grivas, who died of a drug overdose in 2008 at age 26.

 

And earlier this month she teased the memoir with solemn statements shared with her nearly one million followers. “I don't have room for inauthenticity or hidden meanings. There's no longer subtext when I speak. Everything I say is true, unadorned, and real,” she declared.

 

“I'm finally free to reveal the true me, and in doing so, I hope in some small way you might be able to come to terms with some of your past too,” the actress said.

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