Truck fell into a 50-metre-deep valley in the wee hours of Wednesday, a police officer said.
Incident has resulted in the death of eight people and 10 have, reportedly, been injured.
The victims, all fruit vendors, started from Savanur and were heading towards the Yellapura fair.
They were travelling on the Savanur-Hubballi road when the accident occurred in a forest area, Uttara Kannada Superintendent of Police M Narayana said.
"Around 5.30 am, the truck driver in a bid to give side to another vehicle went to the extreme left and fell into the valley," Narayana told the media.
He said there was no protection wall on the road.
"Eight people were killed on the spot and two got critical injuries. The injured have been shifted to KIMS hospital in Hubballi," the officer said.